PD1-CD28 FUSION PROTEIN ENABLES CD4+ T CELL HELP FOR ADOPTIVE T CELL THERAPY IN MODELS OF PANCREATIC CANCER AND NON-HODGKIN LYMPHOMA

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Background: Interaction of the programmed death receptor 1 (PD-1) and its ligand, PD-L1, suppresses T cell activity and permits tumors to evade T cell-mediated immune surveillance.We have recently demonstrated that antigen-specific CD8+ T cells transduced with a PD1-CD28 fusion protein are protected from PD-1-mediated inhibition.We have now investi

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Pathology of The Executive Regulations of Article 219 of the Law on Direct Taxes in compliance with legal principles and rules

The Executive Regulations of Article 219 of the Direct Taxes Law is one of the most important executive regulations of this Law, which explains how the tax organization interacts with taxpayers and how the officers perform their duties.The results of this research, which had carried out descriptively and analytically, indicate that the mentioned re

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Public Discourse Surrounding the 2025 California Wildfires: A Sentiment and Topic Analysis of High-Engagement YouTube Comments

This study explores public discourse surrounding the January 2025 California wildfires by analyzing high-engagement YouTube comments.Leveraging sentiment analysis, misinformation detection, and topic modeling, this research identifies dominant emotional tones, harry potter magsafe case thematic patterns, and the prevalence of misinformation in disc

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Different distribution patterns between putative ercoid mycorrhizal and other fungal assemblages in roots of Rhododendron decorum in the Southwest of China.

Fungal diversity within plant roots is affected by several factors such as dispersal limitation, habitat filtering, and plant host preference.Given the differences in life style between symbiotic and non-symbiotic fungi, the main factors affecting these two groups of fungi may be different.We assessed the diversity of root associated fungi of Rhodo

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